The rules, by product
| Product | Normal storage | Room-temperature allowance |
|---|---|---|
| Wegovy single-dose pen or syringe | Refrigerator, 2 to 8 °C | Before the cap is removed: 8 to 30 °C for up to 28 days[1] |
| Wegovy FlexTouch (multi-dose) pen | Refrigerator before first use | After first use: 15 to 30 °C or refrigerator, up to 56 days; discard if exposed above 30 °C or out of the fridge 56 days or longer[1] |
| Wegovy 25 mg tablets | Room temperature, in the original bottle | Not applicable[1] |
| Zepbound single-dose pen or vial | Refrigerator, 2 to 8 °C | Up to 30 °C for a total of 21 days, then discard[2] |
| Zepbound KwikPen or multi-dose vial | Refrigerator | Unopened at room temperature: discard after 30 days[2] |
| Mounjaro single-dose pen or vial | Refrigerator, 2 to 8 °C | Up to 30 °C for a total of 21 days, then discard[3] |
| Ozempic pen | Refrigerator before first use | After first use: 15 to 30 °C or refrigerator, 56 days; single-dose pen or syringe before use: 8 to 30 °C up to 28 days[4] |
All four labels say: do not freeze, and do not use a pen that has been frozen; keep it in the carton to protect it from light.[1][2][3][4]
Frozen, hot, or left out
The labels give rules, not a test. A frozen pen is to be discarded, even if it looks normal.[1][2][3][4] A pen left in a hot car above 30 °C is outside every label's allowance; the Wegovy label says to throw away a FlexTouch pen that has been exposed to temperatures above 30 °C.[1] "Left on the counter overnight" at ordinary room temperature is inside the allowance for all of them, as long as the total days are counted.[1][2][3][4] When in doubt, the pharmacy that dispensed it can advise, and some manufacturers' helplines will too.
Travelling
The room-temperature allowances exist for exactly this. A trip under 21 days (tirzepatide) or 28 days (Wegovy single-dose) is inside the label as long as the pen stays below 30 °C and out of direct light.[1][2][3] Checked luggage holds can freeze; the label's "do not freeze" is the stronger rule.
Heard vs evidence
The short version
Short on the way. A 35-second captioned version of this page is in production for the Fewer Bites channel. It will be embedded here when it is live.
Questions to bring to your prescriber
Print these or screenshot them. They are conversation starters, not a checklist of things to do.
- Which pen type do I have, and which storage rule applies to it?
- My pen was left out or got warm: should I use it, and who can check for me?
- I am travelling for longer than the room-temperature allowance; how should I plan?
Education, not advice. This page explains what trials, labels and guidelines report. It does not tell anyone to start, change or stop a medicine. Your prescriber knows your history; this page does not.
Sources
- Novo Nordisk / FDA. Wegovy (semaglutide) injection and tablets, prescribing information, revised 06/2026. label
- Eli Lilly / FDA. Zepbound (tirzepatide) prescribing information, revised 08/2026. label
- Eli Lilly / FDA. Mounjaro (tirzepatide) prescribing information, revised 08/2026. label
- Novo Nordisk / FDA. Ozempic (semaglutide) prescribing information, revised 05/2026. label