GLP-1 Help

From the forums · Question 31 of 35

Feeling cold all the time

This comes up again and again in forums. It is not in the labels and has not been studied. Here is what we can say honestly.

By Dr. Chiranjeevi Peetla · Updated November 2026 · 2 min read · 3 sources, each linked

Why this page exists: this question comes up often in GLP-1 patient forums but rarely in search results. We sampled forum threads by title; we did not quote or identify any user.

What is known

Feeling cold is not among the adverse reactions listed in the Wegovy or Zepbound labels.[1][2] We found no trial or study that measured body temperature or cold sensitivity in people on these drugs.

Possible explanations

Eating less means the body produces less heat from digesting food, and intake falls by roughly a quarter to a third on these drugs.[3] Losing body fat removes some insulation. Both are reasonable ideas; neither has been tested in GLP-1 users.

When to get checked

Feeling cold with tiredness, dry skin, constipation and hair thinning can also be a sign of an underactive thyroid, which is common and easy to test. Feeling cold with dizziness can be a sign of low blood pressure; see dizziness.

The short version

Short on the way. A 35-second captioned version of this page is in production for the Fewer Bites channel. It will be embedded here when it is live.

Questions to bring to your prescriber

Print these or screenshot them. They are conversation starters, not a checklist of things to do.

  • Is it worth checking my thyroid or blood count?
  • Am I eating enough for the rate I am losing weight?

Education, not advice. This page explains what trials, labels and guidelines report. It does not tell anyone to start, change or stop a medicine. Your prescriber knows your history; this page does not.

Sources

Every number on this page traces to one of these. "Primary read" means the full paper or label was read; "abstract only" means only the abstract was available; "secondary" means the figure was taken from a named review.

  1. Novo Nordisk / FDA. Wegovy (semaglutide) injection and tablets, prescribing information, revised 06/2026. label
  2. Eli Lilly / FDA. Zepbound (tirzepatide) prescribing information, revised 08/2026. label
  3. Christensen S et al. Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: a narrative review. Obesity Pillars 2024. secondary · review

Using

Tiredness

Read

Eating

What to eat

Read

Using

Hair loss

Read

Forums

Dizziness

Read

All 35 questions